Human Pulmonary Fibroblasts (HPF)

Product Description

The most abundant cell type in lung interstitium is fibroblasts. They resemble ordinary fibroblasts but have some distinguishing features, such as long branching processes and gap junctions. The main function of human pulmonary fibroblasts (HPF) is to produce type III collagen, elastin, and proteoglycans of the extracellular matrix of the alveolar septa. Human pulmonary fibroblasts (HPF) play an important role in the repair and remodeling processes following injury. The controlled accumulation of fibroblasts to sites of inflammation is crucial for effective tissue repair after injury [1]. Either inadequate or excessive accumulation of fibroblasts can result in abnormal tissue function. For example, the excess proliferation of fibroblasts contributes to the adventitial thickening observed during the development of hypoxia-induced pulmonary hypertension [2]. 

iXCells Biotechnologies provides high quality HPF, which are isolated from human lung tissue and cryopreserved at P0, with >0.5 million cells in each vial. HPF express fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 16 population doublings in Fibroblast Growth Medium (Cat# MD-0011) under the condition suggested by iXCells Biotechnologies.

Product Details

References

[1] Kuwano K, Hagimoto N, Hara N. (2001) Molecular mechanisms of pulmonary fibrosis and current treatment. Curr Mol Med 1(5):551-73. 
[2] Das M, Dempsey EC, Reeves JT, Stenmark KR. (2002) Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 282(5):L976-86.