Human Bronchial Fibroblasts (HBF)

Product Description

The most abundant cell type in the bronchus is fibroblasts. Human Bronchial Fibroblasts (HBF) display a mesenchymal stem cell phenotype and their principle function is to produce type III collagen, elastin, and proteoglycans of the extracellular matrix [1]. Bronchial fibroblasts play an important role in the repair and remodeling processes following injury. The controlled accumulation of fibroblasts to sites of inflammation is crucial for effective tissue repair after injury [2]. Either inadequate or excessive accumulation of fibroblasts can result in abnormal tissue function. For example, the excess fibroblast proliferation and collagen secretion that occurs from bronchial subepithelial fibrosis can result in airway obstruction and bronchial hyper-responsiveness [3]. 

iXCells Biotechnologies provides high quality HBF, which are isolated from human bronchus tissue and cryopreserved at P1, with >0.5 million cells in each vial. HBF express fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand in Fibroblast Growth Medium (Cat# MD-0011) under the condition suggested by iXCells Biotechnologies.  

Figure 1. Phase Contrast of Human Bronchial Fibroblasts (HBF)

Product Details

References

[1] Sabatini, F., Petecchia, L., Tavian, M., Jodon de Villeroche, V., Rossi, GA,. Brouty-Boye, D. (2005) Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Lab Invest 85(8):962-71.
[2] Kuwano K, Hagimoto N, Hara N. (2001) Molecular mechanisms of pulmonary fibrosis and current treatment. Curr Mol Med 1(5):551-73.
[3] Hoshino, M., Nakamura, Y., Sim, J., Isoqai, S. (1998) Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflamaiton. J Allergy Clin Immunol 102(5): 783-8. ScienCellResearch LaboratoriesTM.

 Download Datasheet